Instruments
- Pearl Imager (Licor) designed for in vivo imaging in the near-infrared (NIR) spectral region.
- IVIS 200 Xenogen for Bioluminescence based Optical Imaging (c/o University of Torino).
- Explore Optix (GE) for NIR fluorescence Optical Imaging (c/o CBM, Trieste).
- OI contrast agents experimental for preclinical imaging are available. If necessary, labelling and/or smart probes are prepared on request.
Services
The activities include the set up of the service/instrumentation/animal models for OI.
- Activities on three OI equipments allowing functional imaging experiments in mice and rats.
- Labelling of antibodies , proteins and chemicals.
- Imaging of receptor-targeted fluorophore agents, blood pool imaging agents, smart probes.
- Biodistribution and pharmacokinetics of fluorophore labelled compounds.
- Stem cell labelling and tracking.
Description
The availability, in this platform, of three state-of-the-art optical imaging instruments allows to perform different kinds of experiments:
- Oncology -> Imaging on Transgenic and Xenografts models (tumor biology, apoptosis , angiogenesis, drug efficacy evaluation).
- Drug absorption /distribution and metabolism
- Cell migration
- Gene expression and optical reporter proteins (luciferase, GFP)
- Inflammation -> Imaging on induced pathological models (arthritis, macrophage detection)
Gallery
